Antidepressant mechanism of Jieyu No. 1 decoction in a rat model of depression

作者：Zhang, Liping; Wu, Li; Xia, Meng^*; Shi, Xueli; Zhang, Man; Tan, Chi; Yang, Rui

来源：Neural Regeneration Research, 2011, 6(18): 1386-1390.

DOI：10.3969/j.issn.1673-5374.2011.18.005

• modified Wendan decoction
• depression
• model
• animal
• neuroimmunoendocrine
• neural regeneration

Rats were subjected to unpredictable chronic stress and isolation-induced depression, and were then intragastrically perfused with Jieyu No.1 decoction or amitriptyline water solution for 21 consecutive days. Open-field test showed that Jieyu No.1 decoction and amitriptyline water solution significantly improved the abnormal behaviors of the depressed rats; it reduced plasma surfactant protein, corticosterone, and corticotropin releasing hormone levels, increased neuropeptide Y and somatostatin levels, and upregulated interleukin-1 beta, -2, -6 protein expression in the hippocampal CA3 region. Somatostatin and interleukin-1 beta protein expression were negatively correlated with corticosterone level, and interleukin-1 beta protein expression was negatively correlated with corticotropin releasing hormone level. Results demonstrated that Jieyu No.1 decoction improved abnormal behaviors of depressed animals by regulating the function of the neuroimmunoendocrine system.

• 出版日期2011-6
• 单位广西中医药大学