Parietal lobe volume deficits in schizophrenia spectrum disorders

作者：Zhou, Shi Yu; Suzuki, Michio^*; Takahashi, Tsutomu; Hagino, Hirofumi; Kawasaki, Yasuhiro; Matsui, Mie; Seto, Hikaru; Kurachi, Masayoshi

来源：Schizophrenia Research, 2007, 89(1-3): 35-48.

DOI：10.1016/j.schres.2006.08.032

• schizophrenia
• schizotypal disorder
• parietal lobe
• volume
• asymmetry
• magnetic resonance imaging

There has been little attention given to whether parietal lobe structural deficits are present in patients with schizophrenia and related personality disorders. The Current study was designed to examine parietal volume afterations between schizophrenia and schizotypal personality disorder. Twenty-five patients with schizotypal disorder, 53 patients with schizophrenia, and 59 healthy volunteers were scanned using high-resolution magnetic resonance imaging (MRI). Volume measurements of the postcentral gyrus (PoCG), precrineus, superior parietal gyrus (SuPG), supramarginal gyrus (SMG), and angular gyrus (AGG) were performed oil consecutive 1-mm coronal slices. Gray matter volumes were reduced in all parietal subregions in patients with schizophrenia compared with healthy controls. White matter volumes were also reduced in the SuPG and PoCG. fit contrast, the schizotypal subjects had gray matter reductions only in the PoCG, while other regions were not affected. In addition, there was a lack of normal significant-leftward asymmetry in the SMG in schizophrenia. These findings demonstrate that volume reductions in the somatosensory cortices are common morphological characteristics in schizophrenia spectrum disorders. The additional volume alterations in schizophrenia may support the notion that a deficit in the posterior parietal region is critical for the manifestation of overt psychotic symptoms.

• 出版日期2007-1
• 单位大连医科大学