Hsp-90 Inhibitor Geldanamycin Attenuates Liver Oxidative Stress and Toxicity in Thiram-Induced Tibial Dyschondroplasia

作者：Shahzad, Muhammad; Liu, Jingying; Gao, Jianfeng; Wang, Zhi; Zhang, Ding; Nabi, Fazul; Li, Jiakui^*

来源：Pakistan Veterinary Journal, 2014, 34(4): 545-547.

• 17-DMAG
• Biochemical changes
• Thiram
• Tibial dyschondroplasia

An experiment was conducted to study the effects of hsp90 inhibitor geldanamycin (17-DMAG) on liver functioning and its antioxidant ability in thiram-induced tibial dyschondroplasia. One hundred and twenty commercial chicken broilers were allocated into three groups: 1) control, 2) thiram-induced and 3) 17-DMAG treated. Serum samples were collected on day 11 and 14 post-hatch to determine the liver ALT, AST and ALP activity. The liver samples were collected at the end of trial to determine the activity of SOD (superoxide dismutase), GSH-Px (glutathione peroxidase) and MDA (malondialdehyde) contents. The results depicted that thiram increased the level of serum ALT, AST and liver MDA contents while decreased the serum ALP and liver antioxidant enzymes (SOD, GSH-Px); however, by administering 17-DMAG, these values were observed close to normal range as compared to control group. In conclusion, the oxidative imbalance and damage to liver caused by thiram can be restored by using 17-DMAG.

• 出版日期2014
• 单位华中农业大学