Antihyperglycemic effect of Persea duthieion blood glucose levels and body weight in alloxan induced diabetic rabbits

作者：Sultan Khushbakht; Zakir Muhammad; Khan Haroon; Khan Ihsaan Ullah; Ayaz Sultan; Khan Iqbal; Khan Jafar; Khan Murad Ali^*

来源：Pakistan Journal of Pharmaceutical Sciences, 2016, 29(3): 837-842.

• Persea duthiei
• extract/fractions
• antihyperglycemic activity

The present study was designed to investigate the antihyperglycemic effect of Persea duthieion blood glucose concentration and body weight in alloxan induced diabetic hyperglycemic rabbits. The results illustrated significant antihyperglycemic activity of crude extract with 17.44% and 28.02% amelioration at 25 and 50mg/kg p.o. respectively after 24th day of drug treatment; equally supported by body weight recovery. Upon fractionation, most dominant antihyperglycemic effect was displayed by aqueous fraction with 22.12% and 34.43% effect followed by ethyl acetate fraction with 24.32% and 32.05% effect at 25 and 50mg/kg p.o. respectively after 24th day of drug treatment. The effect on blood glucose was also reflected on body weight of animals. In conclusion, our study documented marked antihyperglycemic activity of extract/fractions of P. duthiei.

• 出版日期2016-5