A new diketopiperazine isolated from a Nocardiopsis strain TRM20105 guided by bioassay against Candida albicans

作者：Chen, Haolun; Wan, Chuanxing^*; Zhang, Lili

来源：Natural Product Research, 2019, 33(23): 3421-3425.

DOI：10.1080/14786419.2018.1475389

• Nocardiopsis
• diketopiperazine
• antifungal activity
• 1-demethylnocazine A

An actinomycete strain TRM20105 with antifungal activity was identified as Nocardiopsis dassonvillei subsp. dassonvillei DSM43111 (98.34% similarity) by 16S rDNA phylogenetic analysis and morphology observation. The fermentation broth of TRM20105 cultured with oat-soybean medium was subjected to discover bioactive compounds. Guided by antifungal bioassay against Candida albicans, a new diketopiperazine compound was purified via various column chromatographies together with pHPLC. The purified active compound was identified as 1-demethylnocazine A, (3Z,6Z)-5-methoxy-3,6-bis(4-methoxybenzylidene) -1,6-dihydropyrazin-2(3H)-one by the analyses of 1D & 2D NMR data.

• 出版日期2019-12-2
• 单位塔里木大学