APOE interacts with age to modify rate of decline in cognitive and brain changes in Alzheimer's disease

作者：Chang Yu Ling; Fennema Notestine Christine; Holland Dominic; McEvoy Linda K; Stricker Nikki H; Salmon David P; Dale Anders M; Bondi Mark W^*

来源：Alzheimer's and Dementia, 2014, 10(3): 336-348.

DOI：10.1016/j.jalz.2013.05.1763

• Alzheimer's disease
• APOE genotype
• Cognition
• Morphometry
• Magnetic resonance imaging
• Longitudinal

Objective: To determine (1) whether age-standardized cognitive declines and brain morphometric change differ between Young-Old patients with Alzheimer's disease (YOAD) and Very-Old patients with Alzheimer's disease (VOAD), and (2) whether the apolipoprotein E (APOE) genotype modifies these neuropsychological and morphometric changes.
Methods: Baseline and 12-month follow-up neuropsychological and morphometric measures were examined for healthy control subjects and patients with AD. The two AD groups were divided further into subgroups on the basis of the presence of at least one APOE epsilon 4 allele.
Results: The YOAD group showed more severe deficits and steeper declines in cognition than the VOAD group. Moreover, the presence of an APOE epsilon 4 allele had a more deleterious effect on the YOAD group than the VOAD group on cognition and brain structure both cross-sectionally and longitudinally.
Conclusions: Results underscore the importance of integrating an individual's age and genetic susceptibility-and their interaction-when examining neuropsychological and neuroimaging changes in the early stages of Alzheimer's disease.

• 出版日期2014-5