A series of 2-O-trifluoromethylsulfonyl-D-mannopyranosides as precursors for concomitant F-18-labeling and glycosylation by click chemistry

作者：Maschauer Simone; Prante Olaf^*

来源：Carbohydrate Research, 2009, 344(6): 753-761.

DOI：10.1016/j.carres.2009.02.001

• F-18-Labeling
• Glycosylation
• Click chemistry
• 1,3-Dipolar cycloaddition
• PET
• F-18

A series of 'clickable' mannopyranosides bearing a triflate leaving group at C-2 position were synthesized and tested for their potential as F-18-labeling precursors. 3,4,6-Tri-O-acetyl-2-O-trifluoromethanesulfonyl-beta-D-mannopyranosyl azide (2 beta) was the most convenient precursor for a site-specific and reliable click chemistry-based three-step, two-pot concomitant F-18-labeling and glycosylation of an alkyne-functionalized amino acid derivative.

• 出版日期2009-4-21