Aminofluorination of 2-alkynylanilines: a Au-catalyzed entry to fluorinated indoles

作者：Arcadi Antonio^*; Pietropaolo Emanuela; Alvino Antonello; Michelet Veronique

来源：Beilstein Journal of Organic Chemistry, 2014, 10: 449-458.

DOI：10.3762/bjoc.10.42

• 2-alkynylanilines
• fluorination
• gold catalysis
• indoles
• tandem reactions

The scope and limitations of gold-catalyzed tandem cycloisomerization/fluorination reactions of unprotected 2-alkynylanilines to have access to 3,3-difluoro-2-aryl-3H-indoles and 3-fluoro-2-arylindoles are described. An unprecedented aminoauration/oxidation/ fluorination cascade reaction of 2-alkynylanilines bearing a linear alkyl group on the terminal triple bond is reported.

• 出版日期2014-2-20