A New Access to the 6,8-Dioxabicyclo[3.2.1]octane Ring System Using a Three-Component Reaction: Enantioselective Synthesis of (+)-iso-exo-Brevicomin

作者：Bouziane Asmae; Regnier Thomas; Carreaux Francois^*; Carboni Bertrand; Bruneau Christian; Renaud Jean Luc

来源：Synlett, 2010, (2): 207-210.

DOI：10.1055/s-0029-1218561

• natural product
• asymmetric catalysis
• cycloaddition
• boron
• redox isomerization

The combination of a catalytic hetero-Diels-Alder-allylboration sequence and a ruthenium-catalyzed isomerization of an allylic alcohol moiety as key steps open a new route for the asymmetric synthesis of 6,8-dioxabicyclo[3.2.1]octane subunits. The application of this strategy to the synthesis of (+)-iso-exo-brevicomin is also reported.

• 出版日期2010-1