科研之友
微信
新浪微博
Facebook
分享链接
摘要
Purpose: Studies have come to conflicting conclusions about whether CYP19 polymorphisms are associated with endometriosis risk. To help resolve this question, we carried out a meta-analysis of case-control studies in the literature. Methods: All eligible case-control studies published up to Dec. 16, 2015 were identified by searching PubMed, Embase, the Chinese Biological Medical Database and the Chinese National Knowledge Infrastructure Database, without language restrictions. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were calculated. Results: A total of nine eligible articles with sixteen studies were included. Overall, no evidence indicated that the rs10046 polymorphism was associated with endometriosis risk. However, after stratification by ethnicity, a lower risk of endometriosis was found with rs10046 among Caucasians under the allele model. For the rs700519 polymorphism, a lower risk of endometriosis was found among Asians using the recessive and heterozygous models. No significant association was observed between the rs2236722 and rs700518 polymorphisms and endometriosis risk among Asians. Conclusions: Our meta-analysis detected that the CYP19 rs10046 polymorphism might be associated with endometriosis risk among Caucasians and the rs700519 polymorphism might be associated with endometriosis risk among Asians, while the rs700518 and rs2236722 polymorphisms might not be associated with endometriosis risk among Asians.
- 出版日期2016
- 单位中国人民解放军第三〇九医院; 中国人民解放军总医院
