Application of Proteomic Tools in Modern Nanotechnological Approaches Towards Effective Management of Neurodegenerative Disorders

作者：Ali Ashraf; Sheikh Ishfaq Ahmed; Mirza Zeenat; Gan Siew Hua; Kamal Mohammad Amjad; Abuzenadah Adel M; Damanhouri Ghazi A; Ashraf Ghulam Md^*

来源：Current Drug Metabolism, 2015, 16(5): 376-388.

DOI：10.2174/1389200216666141208153303

• Disposition
• nano-applications
• nano-drugs
• nano-techniques
• nanotechnology
• neurological disorders
• proteomics

Neurodegeneration is the progressive loss of structure or function of neurons leading to neuronal death, usually associated with ageing. Some of the common neurodegenerative disorders include Alzheimer's disease, Parkinson's disease, Creutzfeldt-Jakob disease, and Huntington's disease. Due to recent advancements in high-throughput technologies in various disciplines such as genomics, epigenomics, metabolomics and proteomics, there has been a great demand for detection of specific macromolecules such as hormones, drug residues, miRNA, DNA, antibodies, peptides, proteins, pathogens and xenobiotics at nano-level concentrations for in-depth understanding of disease mechanisms as well as for the development of new therapeutic strategies. The present review focuses on the management of age-related neurodegenerative disorders using proteomics and nanotechnological approaches. In addition, this review also highlights the metabolism and disposition of nano-drugs and nano-enabled drug delivery in neurodegenerative disorders.

• 出版日期2015