科研之友
微信
新浪微博
Facebook
分享链接
摘要
Vascular endothelial growth factor (VEGF) regulates angiogenesis during the development of psoriasis, yet it is unclear whether the VEGF -460T/C and +405G/C polymorphisms associated with psoriasis risk. Here, a case-control study in a Chinese Han population and a meta-analysis were conducted to further investigate these associations. This case-control study involved 248 Han Chinese cases and 259 gender-and age-matched healthy controls, which were genotyped using polymerase chain reaction-ligation detection reaction (PCR-LDR) method. The results together with data from previous studies were meta-analyzed. Our case-control study suggested the -460T/C and + 405G/C polymorphisms were not associated with psoriasis, but subgroup analysis by gender indicated a significant association with decreased risk of psoriasis in male subjects under heterozygote (OR = 0.60, 95% CI = 0.39-0.93, P = 0.022), dominant (OR = 0.59, 95% CI = 0.39-0.91, P = 0.016), and allele (OR = 0.70, 95% CI = 0.50-0.97, P = 0.031) models of the -460T/C polymorphism. Similarly, the meta-analysis including the present study (six studies on -460T/C and nine studies on + 405G/C) showed no associations between the two polymorphisms and psoriasis. However, subgroup analysis by ethnicity revealed a significant association with decreased risk of psoriasis in Caucasians under both heterozygote (OR = 0.68, 95% CI = 0.50-0.92, P-h = 0.794, I-2 = 0.0%) and dominant (OR = 0.73, 95% CI = 0.55-0.97, P-h = 0.371, I-2 = 0.0%) models of the -460T/C polymorphism and in Asians under allele (OR = 0.85, 95% CI = 0.77-0.93, P-h = 0.502, I-2 = 0.0%) model of the +405G/C polymorphism. The meta-analysis and our case-control study respectively suggest the -460T/C polymorphism confers decreased risk to psoriasis in Caucasians and male Han Chinese, and that the +405G/C polymorphism confers decreased risk to psoriasis in Asians, but not in a Chinese Han population.
