A case of multiple vertebral compression fractures due to glucocorticoid-induced osteoporosis in a pediatric patient with nephrotic syndrome

作者：Ashida Akira; Fujii Yuko; Matsumura Hideki; Tamai Hiroshi

来源：International Journal of Clinical Pharmacology and Therapeutics, 2017, 55(3): 264-269.

DOI：10.5414/CP202732

• steroid-resistant nephrotic syndrome
• vertebral compression fracture
• glucocorticoid-induced osteoporosis

Introduction: Glucocorticoid therapy has a number of adverse effects, among which osteoporosis and bone fracture can be major complications. Immunosuppressive therapy for nephrotic syndrome is effective and can help to reduce the cumulative dose of glucocorticoids. Therefore, for this reason, the number of patients with nephrotic syndrome who develop glucocorticoid-related osteoporotic compression fracture is decreasing. Here we describe a pediatric case of multiple vertebral compression fractures due to glucocorticoid-induced osteoporosis during treatment for nephrotic syndrome. Case presentation: A 12-year-old boy with nephrotic syndrome was treated with the standard corticosteroid regimen stipulated by the International Study of Kidney Disease in Children (ISKDC). Although he achieved complete remission, he suffered two episodes of relapse, and after the second such episode, the disease became resistant to the steroid therapy. Therefore, the patient received steroid pulse therapy followed by steroid tapering concomitant with cyclosporine administration. However, similar to 9 months after the start of steroid therapy, the patient developed multiple vertebral compression fractures with severe back pain. Conclusion: It is necessary to evaluate the state of bone at an early stage of treatment for nephrotic syndrome in children, even if the cumulative dose of glucocorticoid is not particularly high.

• 出版日期2017-3