Association of TCF7L2 and GCG Gene Variants with Insulin Secretion Insulin Resistance and Obesity in New-onset Diabetes

作者：Zhang Lu; Zhang Ming; Wang Jin Jin; Wang Chong Jian; Ren Yong Cheng; Wang Bing Yuan; Zhang Hong Yan; Yang Xiang Yu; Zhao Yang; Han Cheng Yi; Zhou Jun Mei; Pang Chao; Yin Lei; Zhao Jing Zhi; Luo Xin Ping^*; Hu Dong Sheng^*

来源：Biomedical and Environmental Sciences, 2016, 29(11): 814-817.

DOI：10.3967/bes2016.108

• Adult
• Cohort Studies
• Diabetes Mellitus, Type 2
• Female
• Humans
• Insulin
• Insulin Resistance
• Male
• Middle Aged
• Obesity
• Polymorphism, Single Nucleotide
• Proglucagon
• Transcription Factor 7-Like 2 Protein

This cohort study was designed to evaluate the association of transcription factor 7-like 2 (TCF7L2) and proglucagon gene (GCG) variants with disordered glucose metabolism and the incidence of type 2 diabetes mellitus (T2DM) in a rural adult Chinese population. A total of 7,751 non-T2DM participants ?18 years old genotyped at baseline were recruited. The same questionnaire interview and physical and blood biochemical examinations were performed at both baseline and follow-up. During a median 6 years of follow-up, T2DM developed in 227 participants. After adjustment for potential contributory factors, nominally significant associations were seen between TT genotype and the recessive model of TCF7L2 rs7903146 and increased risk of T2DM [hazard ratio (HR)=4.068, 95% confidence interval (CI): 1.270-13.026; HR=4.051, 95% CI: 1.268-12.946, respectively]. The TT genotype of rs7903146 was also significantly associated with higher fasting plasma insulin level and the homeostasis model assessment of insulin resistance in case of new-onset diabetes. In addition, the TCF7L2 rs290487 TT genotype was associated with abdominal obesity and the GCG rs12104705 CC genotype was associated with both general obesity and abdominal obesity in case of new-onset diabetes.

• 出版日期2016-11
• 单位深圳大学; 河南中医药大学; 郑州大学