Differences in rapid eye movement sleep behavior disorder manifestation between synucleinopathies and tauopathies

作者：Nomura Takashi^*; Inoue Yuichi; Nakashima Kenji

来源：Sleep and Biological Rhythms, 2013, 11: 82-87.

DOI：10.1111/j.1479-8425.2012.00558.x

• Alzheimer%26apos
• s disease
• dementia with Lewy bodies
• multiple system atrophy
• Parkinson%26apos
• s disease
• progressive supranuclear palsy
• REM sleep behavior disorder
• REM sleep without atonia

Rapid eye movement sleep behavior disorder (RBD) frequently occurs in synucleinopathies including multiple system atrophy, Parkinson%26apos;s disease, and dementia with Lewy bodies despite the clinical course of RBD being different between these disorders. Comparatively, the existence of RBD symptoms is relatively rare in patients with progressive supranuclear palsy, a tauopathy showing atypical parkinsonism compared with Parkinson%26apos;s disease. Moreover, in patients with Alzheimer%26apos;s disease, which is another tauopathy, RBD symptoms are less frequent than dementia with Lewy bodies, although both disorders share commonalities in terms of the existence of cortical dementia. Thus, RBD is thought to be relatively specific to synucleinopathies.

• 出版日期2013-6