Design and synthesis of inhibitors of noroviruses by scaffold hopping

作者：Dou Dengfeng; Mandadapu Sivakoteswara Rao; Alliston Kevin R; Kim Yunjeong; Chang Kyeong Ok; Groutas William C^*

来源：Bioorganic & Medicinal Chemistry, 2011, 19(19): 5749-5755.

DOI：10.1016/j.bmc.2011.08.032

• Scaffold hopping
• Noroviruses
• Inhibitor

A scaffold hopping strategy was employed to identify new chemotypes that inhibit noroviruses. The replacement of the cyclosulfamide scaffold by an array of heterocyclic scaffolds lead to the identification of additional series of compounds that possessed anti-norovirus activity in a cell-based replicon system.

• 出版日期2011-10-1