An Iridoid Glucoside and the Related Aglycones from Cornus florida

作者:He Yangqing; Peng Jiangnan; Hamann Mark T; West Lyndon M*
来源:Journal of Natural Products, 2014, 77(9): 2138-2143.
DOI:10.1021/np5002362

摘要

A new iridoid glucoside, cornusoside A (1), and four new natural product iridoid aglycones, cornolactones AD (25), together with 10 known compounds were isolated from the leaves of Cornus florida. The structures of compounds 15 were established by interpretation of their spectroscopic data. Cornolactone B (3) is the first natural cis-fused tricyclic dilactone iridoid containing both a five- and a six-membered lactone ring. A biosynthesis pathway is proposed for cornolactones C (4) and D (5), the C-6 epimers of compounds 13.