Acoustic and temporal analysis of speech A potential biomarker for schizophrenia

作者：Rapcan Viliam^*; D'Arcy Shona; Yeap Sherlyn; Afzal Natasha; Thakore Jogin; Reilly Richard B

来源：Medical Engineering & Physics, 2010, 32(9): 1074-1079.

DOI：10.1016/j.medengphy.2010.07.013

• Acoustic and temporal analysis
• Speech
• Schizophrenia
• Biomarker
• Vocal pitch
• Energy
• Pause
• Utterance

Currently there are no established objective biomarkers for the diagnosis or monitoring of schizophrenia It has been previously reported that there are notable qualitative differences in the speech of schizophrenics The objective of this study was to determine whether a quantitative acoustic and temporal analysis of speech may be a potential biomarker for schizophrenia
In this study 39 schizophrenic patients and 18 controls were digitally recorded reading aloud an emotionally neutral text passage from a children s story Temporal energy and vocal pitch features were automatically extracted from the recordings A classifier based on linear discriminant analysis was employed to differentiate between controls and schizophrenic subjects
Processing the recordings with the algorithm developed demonstrated that it is possible to differentiate schizophrenic patients and controls with a classification accuracy of 79 4% (specificity = 83 6% sensitivity = 75 2%) based on speech pause related parameters extracted from recordings carried out in standard office (non-studio

• 出版日期2010-11