An efficient route to 4-(substituted benzyl)piperidines

作者：Furman B^*; Dziedzic M

来源：Tetrahedron Letters, 2003, 44(45): 8249-8252.

DOI：10.1016/j.tetlet.2003.09.075

• cyclisation
• piperidines
• Heck reaction

A novel approach to 4-(substituted benzyl)piperidines has been developed. The key steps involve the cyclization of imines bearing an allylsilane in the side-chain followed by the palladium-catalyzed cross-coupling of the resulting 4-methylenepiperidine with organoboronic acids under an atmosphere of oxygen.

• 出版日期2003-11-3