Association between Fibroblast Growth Factor Receptor 4 Gly388Arg Polymorphism and Ischaemic Stroke

作者：Zhang, H. F.; Zhao, K. J.; Yang, P. F.; Fang, Y. B.; Zhang, Y. H.; Liu, J. M.^*; Huang, Q. H.

来源：Journal of International Medical Research, 2012, 40(5): 1708-1714.

DOI：10.1177/030006051204000509

• CHINESE POPULATION
• FGFR4 GLY388ARG POLYMORPHISM
• FIBROBLAST GROWTH FACTOR RECEPTOR
• GENETIC POLYMORPHISM
• ISCHAEMIC STROKE

OBJECTIVE: Fibroblast growth factors (FGEs) and their receptors (FGFRs) play important roles in the vascular system. The FGFR4 rs351855 (Gly388Arg) polymorphism has been shown to be a risk factor for many diseases. This case-control study investigated the association between the FGFR4 Gly388Arg polymorphism and susceptibility to ischaemic stroke in the Chinese population. METHODS: The FGFR4 Gly388Arg polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in patients with ischaemic stroke and healthy controls. RESULTS: Frequencies of genotypes GA and AA, and prevalence of the A allele, were significantly lower in ischaemic stroke patients (n = 952) than in controls (n = 986). Genotype AA and allele A were significantly more frequent in stroke patients with, than in those without, diabetes. CONCLUSION: These results suggested that the GA genotype, AA genotype and A allele of FGFR4 Gly388Arg polymorphism are all associated with decreased risk of ischaemic stroke in the Chinese population.

• 出版日期2012-10
• 单位中国人民解放军沈阳军区总医院; 中国人民解放军第二军医大学