A Genetic Comparison of Brucella abortus Isolates from Animals and Humans by Using an MLVA Assay

作者：Her Moon^*; Kang Sung Il; Kim Jong Wan; Kim Ji Yeon; Hwang In Yeong; Jung Suk Chan; Park Sang Hee; Park Mi Yeoun; Yoo Hansang

来源：Journal of Microbiology and Biotechnology, 2010, 20(12): 1750-1755.

DOI：10.4014/jmb.1005.05039

• Brucella abortus
• MLVA
• epidemiology
• animal
• human

The MLVA assay is known to have a high ability to identify and discriminate Brucella species, so that it can be used as an epidemiological tool to discriminate Brucella isolates originating from restricted geographic sources. In this study, the genetic profiles of 38 B. abortus isolates from humans were analyzed and compared with genotypes from animal isolates in South Korea. As a result, it was found that they did not show high genetic diversity and were compacted. They were clustered together with animal isolates, showing a significant correlation to regional distributions. With its ability to prove a significant genetic correlation among B. abortus isolates from animals and humans in South Korea, the MLVA assay could be utilized as part of a program to control and eradicate brucellosis, one of the major zoonoses. This study represents the first data of genetic correlation of B. abortus isolates from humans and animals in South Korea.

• 出版日期2010-12