Asymmetric aldol reactions catalyzed by the promiscuous aldo-ketoreductase enzyme

作者：Bayat Saadi; Abd Malek Emilia; Yahaya Normi M; Salleh Abu Bakar; Tejo Bimo Ario; Rahman Mohd Basyaruddin Abdul^*

来源：Tetrahedron Letters, 2014, 55(46): 6303-6306.

DOI：10.1016/j.tetlet.2014.09.012

• Promiscuous enzymes
• Aldo-ketoreductase
• Asymmetric
• Aldol reaction

The promiscuous aldo-ketoreductase (AKR) enzyme is used as a sustainable biocatalyst for the first time to catalyze asymmetric aldol reactions in aqueous medium. The reactions between aromatic aldehydes and cyclic/acyclic ketones give the corresponding products in moderate yields and enantioselectivities in the presence of water. The influence of solvents, the mole ratio of substrates, and enzyme concentration are investigated. The mechanism of the AKR1A1-catalyzed aldol reaction is also discussed.

• 出版日期2014-11-12