Stereoselective synthesis of triarylethylenes via copper-palladium catalyzed decarboxylative cross-coupling: synthesis of (Z)-tamoxifen

作者：Cahiez Gerard^*; Moyeux Alban; Poizat Maeel

来源：Chemical Communications, 2014, 50(64): 8982-8984.

DOI：10.1039/c4cc03752a

The first Cu/Pd-catalyzed decarboxylative cross-coupling of 3,3-diarylacrylic acids with aryl bromides is described. Triarylethylenes were obtained in high yields with excellent stereoselectivities. This methodology was successfully applied to the stereoselective synthesis of (Z)-tamoxifen.

• 出版日期2014-8-18