Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

作者：Becker, Annette; Thakur, Basant Kumar; Weiss, Joshua Mitchell; Kim, Han Sang; Peinado, Hector^*; Lyden, David^*

来源：Cancer Cell, 2016, 30(6): 836-848.

DOI：10.1016/j.ccell.2016.10.009

• MESENCHYMAL STEM-CELLS
• TUMOR-DERIVED EXOSOMES
• HUMAN PROSTATE-CANCER
• TISSUE FACTOR
• FAS LIGAND
• IN-VIVO
• INTERCELLULAR TRANSFER
• TRANSFERRIN RECEPTOR
• MELANOMA EXOSOMES
• MICRORNA CONTENT

Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stomal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.

• 出版日期2016-12-12