Dragmacidin E Synthesis Studies. Preparation of a Model Heptacyclic Core Structure

作者:Feldman Ken S*; Ngernmeesn Paiboon
来源:Organic Letters, 2010, 12(20): 4502-4505.
DOI:10.1021/ol1018008

摘要

The conversion of a cycloheptannelated indole platform into the heptacyclic core structure of dragmacidin E proceeded over nine steps. Key sequences include a cyclocondensation to form an intermediate dihydropyrazinone ring and the conversion of a cyclic urea into the cyclic guanidine of the target

  • 出版日期2010-10-15