A new palladium-mediated approach to 4-N-arylamino-1-butanols from peroxidic tetrahydrofuran and primary aromatic amines

作者：Russell Henry F^*; Bremner John B; Bushelle Edghill Jennifer; Lewis Melissa R; Thomas Stacey R; Bates Floyd II

来源：Tetrahedron Letters, 2007, 48(9): 1637-1639.

DOI：10.1016/j.tetlet.2006.12.136

• palladium catalyzed
• ring opening
• 4-amino-1-butanols
• hydrogenation
• tetrahydrofuran hydroperoxide

Reaction of primary aromatic amines with peroxidic tetrahydrofuran (THF) in the presence of hydrogen and 10%, palladium on carbon catalyst results in THF ring opening to give 4-N-arylamino-1-butanols in a good yield. The reaction mechanism is believed to involve a free-radical sequence resulting in an imino alcohol subsequently reduced to product.

• 出版日期2007-2-26