聚乳酸微球的结构和释放性能关系及其模型的研究

作者：潘吉铮; 章莉娟; 钱宇

来源：中国化学工程学报(英文版), 2004, 12(6): 869-876.

• waste hot dipping zinc
• tetrapod-like ZnO whisker
• preparation
• crystal morphology

An oil-in-water (O/W) solvent evaporation method was used to prepare biodegradable microspheresbased on poly(D,L-lactic acid) (PLA). Nifedipine, a hydrophobic drug, was chosen as a model molecule in the studyof drug entrapment and release. Effect of preparation conditions on the size, morphology, drug loading, and releaseprofiles of micropheres was investigated. Based on in vitro release experimental findings, a diffusion/dissolutionmodel was presented for quantitative description of the resulting release behaviors and drug release kinetics fromPLA microspheres analyzed. The mathematical models were used to predict the effect of microstructure on theresulting drug release. It provided an approach to determine the suitable structure parameters for microspheres toachieve desired drug release behaviors.

• 出版日期2004
• 单位华南理工大学