(p40)2-Fc reduces immune-inflammatory response through the activation of T cells in collagen induced arthritis mice

作者：Lee Seon Yeong; Lee Seung Hoon; Park Seong Jeong; Kim Doo Jin; Kim Eun Kyung; Kim Jae Kyung; Yang Se Hwan; Park Sung Hwan; Sung Young Chul; Kim Ho Youn; Cho Mi La^*

来源：Immunology Letters, 2016, 176: 36-43.

DOI：10.1016/j.imlet.2016.05.013

• (p40)2-Fc
• Rheumatoid arthritis
• Osteoclastogenesis

IL-12p40 homodimer, a natural antagonist of IL-12 and IL-23, performs an important role in the expression of proinflammatory cytokines that is essential for Th1 and Th17 immune responses. Here, we reveal the therapeutic and immunosuppressive effect of the IL-12p40 subunit ((p40)(2)-Fc) in an experimental autoimmune arthritis model. We hypothesized that (p40)(2)-Fc may reduce the inflammatory response and the activation of T cells. In this study, we intraperitoneally injected (p40)(2)-Fc into collagen induced arthritis (CIA) mice to identify whether (p40)(2)-Fc attenuates CIA severity. (p40)(2)-Fc reduced the development of CIA, joint inflammation and cartilage destruction. (p40)(2)-Fc also significantly decreased the concentration of serum immunoglobulin as well as the number of T cells and C II specific T cells. In addition, osteoclastogenesis in (p40)(2)-Fc treated mice was down-regulated compared to the mice treated with (p40)(2)-Fc control. We observed that (p40)(2)-Fc treatment alleviates arthritis in mice with CIA, reducing inflammation and osteoclast differentiation. These findings suggest that (p40)(2)-Fc can be a potential therapeutic approach for autoimmune arthritis.

• 出版日期2016-8
• 单位河北医科大学