An efficient and versatile route to the synthesis of 9,10-dihydro-3-formylphenanthrenes

作者：Pratap Ramendra; Ram Vishnu Ji^*

来源：Tetrahedron Letters, 2007, 48(10): 1715-1719.

DOI：10.1016/j.tetlet.2007.01.049

• tetralone
• formylphenanthrene
• 2-oxo-4-sec-amino-5,6-dihydro-2H-benzo[h]chromene-3-carbonitriles
• masked aldehyde
• ring transformation

An innovative and efficient route to the synthesis of 9,10-dihydro-3-formylphenanthrenes 7 has been delineated through the ring transformation of 2-oxo-4-sec-amino-5,6-dihydro-2H-benzo[h]chromene-3-carbonitriles 4 with methyl glyoxaldimethylacetal 5 to masked 3-dimethoxymethyl-1-see-amino-9,10-dihydrophenanthrene-3-carbonitriles 6 followed by deacetalation with Amberlyst 15 in excellent yields.

• 出版日期2007-3-5