Fabrication of a Ti porous microneedle array by metal injection molding for transdermal drug delivery

作者：Li, Jiyu; Liu, Bin; Zhou, Yingying; Chen, Zhipeng; Jiang, Lelun^*; Yuan, Wei; Liang, Liang^*

来源：PLos One, 2017, 12(2): e0172043.

DOI：10.1371/journal.pone.0172043

• VIVO FLUORESCENCE MICROSCOPY
• PRESSURE WAVE DEVICE
• VACCINE DELIVERY
• AMINOLEVULINIC ACID
• POLYMER MICRONEEDLES
• ALZHEIMERS-DISEASE
• SKIN
• ELECTROPORATION
• ENHANCE
• MODEL

Microneedle arrays (MA) have been extensively investigated in recent decades for transdermal drug delivery due to their pain-free delivery, minimal skin trauma, and reduced risk of infection. However, porous MA received relatively less attention due to their complex fabrication process and ease of fracturing. Here, we present a titanium porous microneedle array (TPMA) fabricated by modified metal injection molding (MIM) technology. The sintering process is simple and suitable for mass production. TPMA was sintered at a sintering temperature of 1250 degrees C for 2 h. The porosity of TPMA was approximately 30.1% and its average pore diameter was about 1.3 mu m. The elements distributed on the surface of TPMA were only Ti and O, which may guarantee the biocompatibility of TPMA. TPMA could easily penetrate the skin of a human forearm without fracture. TPMA could diffuse dry Rhodamine B stored in micropores into rabbit skin. The cumulative permeated flux of calcein across TPMA with punctured skin was 27 times greater than that across intact skin. Thus, TPMA can continually and efficiently deliver a liquid drug through open micropores in skin.

• 出版日期2017-2-10
• 单位华南理工大学; 中山大学