Adult-specific insulin-producing neurons in Drosophila melanogaster

作者：Ohhara Yuya; Kobayashi Satoru; Yamakawa Kobayashi Kimiko; Yamanaka Naoki^*

来源：Journal of Comparative Neurology, 2018, 526(8): 1351-1367.

DOI：10.1002/cne.24410

• diuretic hormone 44
• Drosophila melanogaster
• insulin-like peptides
• metamorphosis
• neuronal remodeling
• RRID: AB_2567307
• RRID: AB_528190
• RRID: AB_221568
• RRID: AB_390918
• RRID: AB_2569038
• RRID: AB_760350

Holometabolous insects undergo metamorphosis to reorganize their behavioral and morphological features into adult-specific ones. In the central nervous system (CNS), some larval neurons undergo programmed cell death, whereas others go through remodeling of axonal and dendritic arbors to support functions of re-established adult organs. Although there are multiple neuropeptides that have stage-specific roles in holometabolous insects, the reorganization pattern of the entire neuropeptidergic system through metamorphosis still remains largely unclear. In this study, we conducted a mapping and lineage tracing of peptidergic neurons in the larval and adult CNS by using Drosophila genetic tools. We found that Diuretic hormone 44-producing median neurosecretory cells start expressing Insulin-like peptide 2 in the pharate adult stage. This neuronal cluster projects to the corpora cardiaca and dorsal vessel in both larval and adult stages, and also innervates an adult-specific structure in the digestive tract, the crop. We propose that the adult-specific insulin-producing cells may regulate functions of the digestive system in a stage-specific manner. Our study provides a neuroanatomical basis for understanding remodeling of the neuropeptidergic system during insect development and evolution.

• 出版日期2018-6-1