Anti-inflammatory and anti-asthmatic effects of Viola mandshurica W. Becker (VM) ethanolic (EtOH) extract on airway inflammation in a mouse model of allergic asthma

作者：Lee Mee Young; Yuk Ji Eun; Kwon Ok Kyoung; Kim Hui Seong; Oh Sei Ryang; Lee Hyeong Kyu; Ahn Kyung Seop^*

来源：Journal of Ethnopharmacology, 2010, 127(1): 159-164.

DOI：10.1016/j.jep.2009.09.033

• Asthma
• Viola mandshurica W. Becker
• Airway hyperresponsiveness
• Eosinophilia
• Cytokine

Aim of the study: We investigated the efficacy of Viola mandshurica W. Becker (VM) ethanolic (EtOH) extract in the treatment of bronchial asthma in an ovalbumin (OVA)-induced asthmatic BALB/c mouse model.
Materials and methods: Female BALB/c mice were sensitized with intraperitoneal (i.p.) ovalbumin (OVA) on days 0 and 14, and were next given intranasal OVA on days 28-30. Randomized treatment groups of sensitized mice received VM EtOH extract, dexamethasone, or placebo, orally, from days 28 to 30.
Results: VM EtOH extract significantly inhibited increases in total immunoglobulin E (IgE) and cytokines IL-4 and IL-13 levels in serum and bronchoalveolar lavage fluid (BALF), and also effectively suppressed airway hyperresponsiveness (AHR), eosinophilia, and mucus hypersecretion, in mice with OVA-induced asthma.
Conclusions: The results suggest that VM EtOH extract and allied extracts could be useful herbal medicines for asthma treatment, and that VM may also be a valuable lead material for anti-asthma drug development.

• 出版日期2010-1-8