The Role of Primary Colectomy After Successful Endoscopic Stenting in Patients With Obstructive Metastatic Colorectal Cancer

作者：Lee Hyun Jung; Park Soo Jung; Min Byung So; Cheon Jae Hee; Kim Tae Il; Kim Nam Kyu; Kim Won Ho; Hong Sung Pil^*

来源：Diseases of the Colon & Rectum, 2014, 57(6): 694-699.

DOI：10.1097/DCR.0000000000000061

• Colorectal neoplasms
• Malignant obstruction
• Self-expandable metal stents
• Primary colectomy
• Stoma

BACKGROUND: Although the initial clinical efficacy of self-expandable metal stents is acceptable, doubt still remains about long-term clinical outcomes and complications.
OBJECTIVE: The aim of this study was to evaluate the stoma formation rate and risk factors for complications after successful stenting in patients with obstructive metastatic colorectal cancer.
DESIGN: This was a tertiary-care center retrospective study.
PATIENTS: From January 2000 to December 2010, 130 patients with unresectable obstructive colorectal cancer received successful self-expandable metal stent placement. Among them, 14 patients received primary colectomy after successful stenting.
INTERVENTIONS: Self-expandable metal stent placement and primary colectomy were performed.
MAIN OUTCOME MEASURES: The stoma formation rate and complications were measured.
RESULTS: In patients with successful stenting, stoma formation rates at 1 and 2 years were 15.6% (95% CI, 8.74-22.4) and 24.4% (95% CI, 13.8-35.0), and the median patency duration was 157 days (range, 2-1590 days). However, long-term complications occurred in 58 patients (44.6%), including reobstruction (32.6%), stent migration (10.3%), and perforation (7.8%), and a large number of reinterventions (45.7%) and hospitalizations (37/9%) were needed to manage complications. In multivariate analysis, primary colectomy after successful endoscopic stenting was a negative predictive factor for reobstruction (OR, 0.12; 95% CI, 0.02-0.99; p = 0.04).
LIMITATIONS: This was a retrospective, single-center study.
CONCLUSIONS: To reduce stent-related late complications, primary colectomy after successful endoscopic stenting could be a therapeutic option in patients who have unresectable colorectal cancer with obstruction, especially in those who expect long-term survival.

• 出版日期2014-6