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摘要
The construction and performance characteristics of new sensitive and selective sensors based on functionalized multi-walled carbon nanotubes/beta-cyclodextrin nanocomposite (FMWCNTs/beta-CD) was demonstrated for potentiometric determination of different anti-inflammatory agents including lornoxicam, meloxicam, piroxicam and tenoxicam. Screen printed sensors (SPEs) modified with FMWCNTs/beta-CD composite, hyamine (Hy) and 2-fluorophenyl 2-nitrophenyl ether (f-PNPE) showed proper electroanalytical performances with a Nernstian compliance range between 61.2 and 52.6 mV decade(-1) activity and a detection limit of 6.0 x 10(-7) mol L-1 for different oxicam derivatives. Modification with carbon nanotube composite as sensing material remarkably improved the potential stability and lifetime of the fabricated sensors. The proposed sensors offer a simple analytical tool for determination of different oxicam derivatives in their pharmaceutical formulations under batch and flow injection analysis (FIA) conditions.
- 出版日期2015
