MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer

作者：Gayral Marion; Jo Sebastien; Hanoun Naima; Vignolle Vidoni Alix; Lulka Hubert; Delpu Yannick; Meulle Aline; Dufresne Marlene; Humeau Marine; du Rieu Mael Chalret; Bournet Barbara; Selves Janick; Guimbaud Rosine; Carrere Nicolas; Buscail Louis; Torrisani Jerome; Cordelier Pierre^*

来源：World Journal of Gastroenterology, 2014, 20(32): 11199-11209.

DOI：10.3748/wjg.v20.i32.11199

• MicroRNAs
• Biomarkers
• Pancreatic cancer
• Therapeutic targets
• Precancerous lesions

Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma (PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients (80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are desperately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC.

• 出版日期2014-8-28