SNCA Gene Polymorphism may Contribute to an Increased Risk of Alzheimer's Disease

作者：Wang, Quanbao; Tian, Qian; Song, Xiaojie; Liu, Yunyong; Li, Wei^*

来源：Journal of Clinical Laboratory Analysis, 2016, 30(6): 1092-1099.

DOI：10.1002/jcla.21986

• Alzheimer's disease
• Polymorphism
• Risk
• rs10516846
• SNCA

BackgroundThe purpose of this study is to elucidate the association between -synuclein (SNCA) polymorphisms and the risk of Alzheimer's disease (AD). @@@ MethodsThe PCR-RFLP was applied to detect SNCA gene rs6532190, rs3775430, and rs10516846 polymorphisms in 98 AD patients and 105 healthy elderly. @@@ ResultsThe GG frequency of rs10516846 was evidently increased in AD group than control group (P < 0.05). There was a significant difference in SNCA level between the AD and control groups (P < 0.01). In the AD group, the SNCA level in cerebrospinal fluid of GG (rs10516846) carriers was increased as compared with AA carriers (P < 0.05). The GG (rs10516846) frequency of the early-onset AD group is significantly higher than that of the late-onset AD group (P < 0.05). The frequency of rs3775430 GG was lower in the early-onset group than that in the late-onset group (0% vs. 16.7%). The SNCA level in cerebrospinal fluid of GG (rs10516846) carriers in the early-onset AD group is higher than that of AA carriers (P < 0.05). @@@ ConclusionSNCA gene polymorphism may be associated with an increased risk of AD and GG genotype of rs10516846 and elevated SNCA level in CSF may increase the risk of early-onset AD.

• 出版日期2016-11
• 单位临沂市人民医院