Delta(9)-Tetrahydrocannabinol regulates the p53 post-translational modifiers Murine double minute 2 and the Small Ubiquitin MOdifier protein in the rat brain

作者：Gowran Aoife^*; Murphy Carrie E; Campbell Veronica A

来源：FEBS Letters, 2009, 583(21): 3412-3418.

DOI：10.1016/j.febslet.2009.09.056

• Cannabinoid
• Delta(9)-Tetrahydrocannabinol
• Murine double minute
• Small Ubquitin-like MOdifier
• Post-translational modification
• Signal transduction

The phytocannabinoid Delta(9)-Tetrahydrocannabinol (Delta(9)-THC), the main psychoactive cannabinoid in cannabis, activates a number of signalling cascades including p53. This study examines the role of Delta(9)-THC in regulating the p53 post-translational modi. er proteins, Murine double minute (Mdm2) and Small Ubquitin-like MOdifier protein 1 (SUMO-1) in cortical neurons. Delta(9)-THC increased both Mdm2 and SUMO-1 protein expression and induced the deSUMOylation of p53 in a cannabinoid receptor type 1 (CB1)-receptor dependent manner. We demonstrate that Delta(9)-THC decreased the SUMOylation of the CB1 receptor. The data reveal a novel role for cannabinoid receptor activation in modulating the SUMO regulatory system.

• 出版日期2009-11-3