An efficient practical chemo-enzymatic protocol for the synthesis of pyrazoles in aqueous medium at ambient temperature

作者：Mane Ananda; Salokhe Prabha; More Pallavi; Salunkhe Rajashri^*

来源：Journal of Molecular Catalysis B: Enzymatic , 2015, 121: 75-81.

DOI：10.1016/j.molcatb.2015.05.020

• Baker's yeast
• Aqueous medium
• Pyrazoles
• Biocatalysis

An expeditious oxidative cyclocondensation reaction of hydrazines/hydrazides with 1,3-dicarbonyl compound was efficiently developed in aqueous medium using Saccharomyces cerevisae (baker's yeast) as a whole cell biocatalyst at room temperature. The method has been assigned using green chemistry measures and found to give a range of N-substituted pyrazoles with moderate to excellent yields (70-92%). The reaction progress was monitored by gas chromatography.

• 出版日期2015-11