A theoretical study on the advantage of core-shell particles with radially-oriented mesopores

作者：Deridder Sander; Catani Martina; Cavazzini Alberto; Desmet Gert^*

来源：Journal of Chromatography A, 2016, 1456: 137-144.

DOI：10.1016/j.chroma.2016.05.062

• Core-shell particles
• Radially oriented pores
• Computational fluid dynamics
• Simulations
• General plate height model
• B-term band broadening

We report on a first-principles numerical study explaining the potential advantage of core-shell particles with strictly radially-oriented mesopores. Comparing the efficiency of these particles with fully porous and core-shell particles with a conventional (i.e., randomly oriented) mesopore network, the present numerical study shows a similar strong reduction in minimal reduced plate height (h(min)) as was very recently observed in an experimental study by Wei et al. (respectively a h(min)-reduction on the order of about 1 and 0.5 reduced plate height-units). As such, the present work provides a theoretical basis to understand and confirm their experimental findings and quantifies the general advantage of "radial-diffusion-only" particles. Determining the effective longitudinal diffusion (B-term contribution) in a series of dedicated, independent simulations, it was found that this contribution can be described by a very simple, yet fully exact mathematical expression for the case of "radial- diffusion-only" particles. Using this expression, the significant increase in efficiency of these particles can be fully attributed to their much smaller B-term band broadening, while their C-term band broadening (representing the mass transfer resistance) remains unaffected.

• 出版日期2016-7-22