A new biflavonoid from the whole herb of Lepisorus ussuriensis

作者：Luo, Jie; Zhou, Wei; Cao, Shuo; Jin, Mei; Zhang, Changhao; Jin, Xuejun; Cui, Jiongmo; Li, Gao^*

来源：Natural Product Research, 2016, 30(13): 1470-1476.

DOI：10.1080/14786419.2015.1110702

• Polypodiaceae
• Lepisorus ussuriensis
• biflavonoid
• anti-inflammatory activity
• nuclear factor-B (NF-kappa B)

A new biflavonoid, 7-O-methylnaringenin-(4O6)-scutellarein (1), together with 11 known compounds (2-12) were isolated from the whole herb of Lepisorus ussuriensis. The structure of compound 1 was elucidated by spectroscopic analyses. Amongst them, dihydroquercetin (6), diosmetin (9), baicalein (11) and 7,8-dihydroxyflavone (12) were reported from the family Polypodiaceae for the first time. Meanwhile, quercetin (7), diosmetin (9) and luteolin (10) inhibited TNF--induced NF-B reporter gene expression on HeLa cells up to 30 and 100 mu M.
[GRAPHICS]
.

• 出版日期2016
• 单位延边大学; 中国人民解放军第二O二医院