Association between polymorphism of the norepinephrine transporter gene rs2242446 and rs5669 loci and depression disorders

作者：Pan, Yu; Cheng, Qi; Shan, Mo-Shui; Yan, Jin^*

来源：International Journal of Clinical and Experimental Medicine, 2015, 8(10): 18837-18842.

• Depression
• norepinephrine transporter gene

Objective: To explore the association between polymorphism of the norepinephrine transporter (NET) gene rs2242446 and rs5669 loci and depression in Chinese Han population. Methods: A case-control study was carried out, the gene types and allele distributions of NFT gene rs2242446 and rs5569 loci in 302 depression patients and 302 healthy controls were detected by Taqman SNP genotyping technology. Results: The gene types and allele frequency distributions of NFT gene rs2242446 and rs5569 loci had significant differences between case group and control group (rs2242446, x(2)=26.045, P<0.05, x(2)=8.827, P<0.05, rs5569, x(2)=42.47, P<0.05, x(2)=20.9, P<0.05). The CC genotype of NET gene rs2242446 locus and rs5569 loci was a protective factor of depression compared with the CT and TT genotypes. Conclusion: The NET genepoly morphism of rs2242446 and rs5569 loci was a ssociated with depression in Chinese Han population, in which the CC genotype of rs2242446 and rs5569 loci was a protective factor of depression.

• 出版日期2015
• 单位中国人民解放军总医院; 中国人民解放军第二军医大学