Antiviral activity of a Rac GEF inhibitor characterized with a sensitive HIV/SIV fusion assay

作者：Pontow Suzanne; Harmon Brooke; Campbell Nancy; Ratner Lee^*

来源：Virology, 2007, 368(1): 1-6.

DOI：10.1016/j.virol.2007.06.022

• HIV-1
• envelope
• rac
• fusion

A virus-dependent fusion assay was utilized to examine the activity of a panel of HIV-1, -2, and SIV isolates of distinct coreceptor phenotypes. This assay allowed identification of entry inhibitors, and characterization of an antagonist of a Rac guanine nucleotide exchange factor, as an inhibitor of HIV-mediated fusion.

• 出版日期2007-11-10