Diffuse Myocardial Injuries are Present in Subclinical Hypothyroidism: A Clinical Study Using Myocardial T1-mapping Quantification

作者：Yao, Zhi; Gao, Xia; Liu, Min; Chen, Zhe; Yang, Ning; Jia, Yu-Mei; Feng, Xiao-Meng; Xu, Yuan; Yang, Xin-Chun^*; Wang, Guang^*

来源：Scientific Reports, 2018, 8(1): 4999.

DOI：10.1038/s41598-018-22970-x

• VENTRICULAR DIASTOLIC FUNCTION
• CORONARY-HEART-DISEASE
• THYROID-DYSFUNCTION
• ALL-CAUSE
• RISK
• MORTALITY
• FAILURE

Subclinical hypothyroidism (SHT) is a common disorder that may represent early thyroid dysfunction and is related to adverse cardiovascular events. However, myocardial injuries induced by SHT are difficult to detect. Our previous study demonstrated that the cardiac magnetic resonance (CMR) myocardial longitudinal relaxation time (T1) mapping technique is a useful tool for assessing diffuse myocardial injuries in overt hypothyroidism patients. This study was designed to detect whether diffuse myocardial injuries were present in SHT by using the T1 mapping technique. We found that SHT participants had significantly increased native T1 values within four segments of the left ventricle (all p < 0.01), especially patients with thyroid-stimulating hormone (TSH) levels >= 10 mu IU/mL, compared with those in the controls. In addition, the native T1 values were negatively correlated with free thyroxine (FT4) (r = -0.476, p = 0.003) and were positively correlated with TSH (r = 0.489, p = 0.002). Furthermore, left ventricular diastolic function estimated by the peak filling rate (PFR) was significantly lower in patients with TSH levels >= 10 mu IU/mL than that in the controls (p < 0.05). In conclusion, diffuse myocardial injuries were present in SHT, and T1 mapping may be a useful tool for evaluating mild myocardial injuries in SHT at an early stage. Our study is the first to confirm myocardial injuries in SHT patients using T1 mapping.

• 出版日期2018-3-22
• 单位首都医科大学; 中日友好医院