Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis

作者：Berntsen Natalie L; Klingenberg Olav; Juran Brian D; de Valle Maria Benito; Lindkvist Bjorn; Lazaridis Konstantinos N; Boberg Kirsten Muri; Karlsen Tom H; Hov Johannes Roksund^*

来源：Gastroenterology, 2015, 148(5): 924-U355.

DOI：10.1053/j.gastro.2015.01.041

• Genetic Association Study
• Immunogenetics
• IgG4-Associated Cholangitis
• Immune Response

Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States. We found an association between levels of IgG4 above the upper reference limit and specific HLA haplotypes. These patients had a significantly lower frequency of the strongest PSC risk factor, HLA-B*08, than patients without increased IgG4, and significantly higher frequencies of HLA-B*07 and HLA-DRB1*15. HLA genotype therefore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.

• 出版日期2015-5
• 单位河北医科大学