Molecular epidemiology of human herpesvirus 8 variants in Kaposi%26apos;s sarcoma from Iranian patients

作者：Jalilvand Somayeh; Tornesello Maria Lina; Buonaguro Franco M; Buonaguro Luigi; Naraghi Zahra Safaie; Shoja Zabihollah; Ziaee Abed Ali; Hamkar Rasool; Shahmahmoodi Shohreh; Nategh Rakhshandeh; Mokhtari Azad Talat^*

来源：Virus Research, 2012, 163(2): 644-649.

DOI：10.1016/j.virusres.2011.09.027

• Kaposi%26apos
• s sarcoma
• Human herpesvirus 8
• ORF26
• ORF K1
• ORF T0.7
• Iran

Kaposi%26apos;s sarcoma (KS) is a rare cancer in Iran and there is no epidemiological and molecular information about HHV-8 variants circulating among the Iranian population. In this study HHV-8 sequences have been analyzed in 43 cutaneous KS biopsies from Iranian patients mainly affected by classic KS. DNA samples were subjected to PCR amplification of HHV-8 ORF26,T0.7 and K1 followed by direct nucleotide sequencing and phylogenetic analysis. The analysis of ORF26 showed that 30 (69.8%) and 13 (30.2%) samples belonged to subtypes A/C and K. respectively. In general, the clustering of HHV-8 T0.7 variants paralleled that of ORF26. Genotyping of K1 sequences showed that the majority of samples (39 out of 41) fall into the large C clade with only 2 belonging to the A clade. In conclusion, HHV-8 variants identified among classic Iranian KS are largely related to Eurasian genotypes previously identified in KS from Mediterranean, Middle East, and East Asian regions.

• 出版日期2012-2