A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants

作者：Fukushima Naoya; Nanao Kenji; Fukushima Hiroyuki; Namera Akira; Miura Masaru^*

来源：European Journal of Pediatrics, 2016, 175(8): 1129-1132.

DOI：10.1007/s00431-016-2722-x

• Clomipramine
• Desmethylclomipramine
• Placental passage
• Prolonged QT interval
• Torsades de Pointes

It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP.
Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.

• 出版日期2016-8