A cyclic glucosyl ceramide acceptor as a versatile building block for complex ganglioside synthesis

作者：Fujikawa Kohki; Nohara Tomohiro; Imamura Akihiro; Ando Hiromune; Ishida Hideharu^*; Kiso Makoto

来源：Tetrahedron Letters, 2010, 51(7): 1126-1130.

DOI：10.1016/j.tetlet.2009.12.121

• Ganglioside
• Intramolecular glycosylation
• Glucosyl ceramide
• Sialic acid

A cyclic glucosyl ceramide (GlcCer) acceptor has been developed as a versatile building block for the synthesis of complex ganglioside. A macrocyclic GlcCer acceptor, which was the product of intramolecular glycosylation between glucose and ceramide, exhibited high reactivity during the coupling reactions with a variety of complex oligosaccharyl donors, thereby furnishing the corresponding ganglioside frameworks in high yields.

• 出版日期2010-2-17