A Novel Taxatetraene Framework Formed From a New Natural Taxane from Taxus cuspidata

作者:Li, Yong; Wang, Yong-Li; Ni, Zhi-Yu; Dong, Mei; Cong, Bin; Sauriol, Francoise; Zhang, Man-Li; Wang, Yu-Fang; Huo, Chang-Hong; Gu, Yu-Cheng; Shi, Qing-Wen*; Kiyota, Hiromasa
来源:Zeitschrift Fur Naturforschung Section B-a Journal of Chemical Sciences, 2011, 66(7): 759-761.
DOI:10.5560/ZNB.2011.66b0759

摘要

Sinenxan H [2 alpha,14 beta-diacetoxytaxa-4(20),11-diene-5 alpha, 10 beta-diol, 1] was isolated from the heartwood of Taxus cuspidata, for the first time from natural sources. Compound 1 was found to be readily converted into 2 alpha-acetoxytaxa-4(20),10,12(18),13-tetraen-5 alpha-ol (2), the first example of a taxane with 10,11- and/or 13,14-double bond(s) and a conjugated triene system, in CDCl3.