Comparison of serum amyloid A and C-reactive protein as diagnostic markers of systemic inflammation in dogs

作者：Christensen Michelle B^*; Langhorn Rebecca; Goddard Amelia; Andreasen Eva B; Moldal Elena; Tvarijonaviciute Asta; Kirpensteijn Jolle; Jakobsen Sabrina; Persson Frida; Kjelgaard Hansen Mads

来源：Canadian Veterinary Journal, 2014, 55(2): 161-168.

The diagnostic performance of canine serum amyloid A (SAA) was compared with that of C-reactive protein (CRP) in the detection of systemic inflammation in dogs. Sera from 500 dogs were retrospectively included in the study. C-reactive protein and SAA were measured using validated automated assays. The overlap performance, clinical decision limits, overall diagnostic performance, correlations, and agreement in the clinical classification between these 2 diagnostic markers were compared. Significantly higher concentrations of both proteins were detected in dogs with systemic inflammation (SAA range: 48.75 to %26gt; 2700 mg/L; CRP range: 0.4 to 907.4 mg/L) compared to dogs without systemic inflammation (SAA range: 1.06 to 56.4 mg/L; CRP range: 0.07 to 24.7 mg/L). Both proteins were shown to be sensitive and specific markers of systemic inflammation in dogs. Significant correlations and excellent diagnostic agreement were observed between the 2 markers. However, SAA showed a wider range of concentrations and a significantly superior overall diagnostic performance compared with CRP.

• 出版日期2014-2