Genetic inactivation of Ikaros is a rare event in human T-ALL

作者：Marcais Ambroise; Jeannet Robin; Hernandez Lucie; Soulier Jean; Sigaux Francois; Chan Susan; Kastner Philippe^*

来源：Leukemia Research, 2010, 34(4): 426-429.

DOI：10.1016/j.leukres.2009.09.012

• T cell acute lymphoblastic leukemia
• Ikaros
• Tumor suppressor
• Cytoplasmic retention

The Ikaros (Ikzf1) gene, encoding a transcription regulator, is a major tumor suppressor in B-cell acute lymphoblastic leukemia (B-ALL). In the mouse, however, loss of Ikaros is primarily associated with T-ALL development. Whether Ikaros is also implicated in human T-ALL remains unclear. We studied Ikaros in 25 human T-ALL samples from diverse molecular subtypes at the mRNA, protein, sequence and genomic copy number level. We found that Ikaros was abnormal in only one sample: one allele was lost by genomic deletion, while proteins generated from the remaining allele were delocalized and concentrated at a single cytoplasmic structure. Thus, inactivation of Ikaros by deletion or mutation is rare in human T-ALL.

• 出版日期2010-4